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The next review deals with doctor analysis of molecular mechanisms of a rare genetic disorder tuberous sclerosis complexTSC, that’s characterised by non cancerous tumors in multi organ techniques in doctor body. An wide review on structuralinformation of TSC1 and TSC2, homology modelling of human TSC1, functional role of TSCc in protein protein interplay,TSC in mTOR pathway, disruptive mutations in TSC, present TSC cure are provided. The biochemical, genetic, structuralbiology, and scientific points of doctor tuberous sclerosis complicated sickness are mentioned as well as drug discovery complications for itscure. The main conclusion is that regardless of massive progress in TSC analysis,the crucial problem in doctor remedy of TSC is tomeet with doctor efficacy of a drug in both CNS as well as tumor growth in numerous parts of doctor body. Another interesting therapeutictarget is doctor TSC1 TSC2 complicated itself . The next paper refers medical doctor Acetyl Cholinesterase AChE, which is doctor key enzyme in doctor hydrolysis of doctor neurotransmitteracetylcholine being doctor target of most of doctor clinically used drugs for doctor treatment of AD.